🔬
Phase III

AZT-4921 (Solid Tumors)

First-in-class KRAS G12C inhibitor with dual MET modulation. Demonstrating robust tumor regression in NSCLC and pancreatic adenocarcinoma cohorts.

8Indications
142Enrolled
68%ORR
🛡️
Phase II

AZT-8834 (Autoimmune Modulation)

Selective JAK3/TEC inhibitor for rheumatoid arthritis and lupus nephritis. Engineered for peripheral tolerance preservation and reduced cytokine storm risk.

3Indications
89Enrolled
Q2 '27Pivotal
🧠
Phase I

AZT-1109 (Neurodegeneration)

BBB-penetrant antisense oligonucleotide targeting tau hyperphosphorylation pathways. Early biomarker reduction observed in AD and PSP models.

2Indications
34Enrolled
SafetyPrimary
🧬
Regulatory

AZT-5502 (Spinal Muscular Atrophy)

AAV9-mediated SMN1 gene replacement with next-generation capsid engineering. Longitudinal motor function improvement sustained at 18-month follow-up.

1Indication
56Cohort
BLAStatus
⚙️
Preclinical

AZT-7719 (CAR-T 3.0 Platform)

Allogeneic TCR-engineered T-cells with safety switch and homing chemokine receptors. Targeting solid tumor microenvironment immune suppression.

5Targets
INDPrep
2026Clinical
📊
Phase II

AZT-3381 (Metabolic Syndrome)

Dual GIP/GLP-1 receptor agonist with extended half-life formulation. Addressing insulin resistance, hepatic steatosis, and cardiovascular risk factors.

4Endpoints
210Enrolled
-18%HbA1c
🦠
Phase III

AZT-9014 (Broad-Spectrum Antiviral)

Oral nucleoside analog with pan-coronavirus and paramyxovirus activity. Novel polymerase exoN bypass mechanism enabling high barrier to resistance.

6Viruses
480Global Sites
92%Viral Clearance
👁️
Target ID

AZT-2205 (Retinal Degeneration)

CRISPR-based epigenetic editor for retinitis pigmentosa. Non-integrating delivery vector preserving endogenous photoreceptor gene expression profiles.

3Models
OptimizationStatus
2027IND Target

Development Pipeline Overview

Target ID
24
Preclinical
18
Phase I
9
Phase II
6
Phase III
3
Regulatory
2
Total Active Programs 62
First-in-Class Candidates 14
Cross-Division Synergies AI/ML, Manufacturing, Clinical Ops

Enabling Technologies

AI-Driven Target Discovery

Proprietary deep learning models analyzing multi-omics datasets to identify novel therapeutic targets with validated disease-modifying potential.

Next-Gen Delivery Systems

Lipid nanoparticle engineering, viral capsid optimization, and antibody-drug conjugate platforms enabling precise tissue tropism and reduced off-target toxicity.

Synthetic Biology Foundries

Automated cell line development, continuous biomanufacturing, and real-time quality control for rapid scale-up from discovery to commercial supply.

Collaborate & License

Explore co-development agreements, clinical trial partnerships, or technology licensing opportunities across our therapeutic portfolio.

Initiate Partnership → View Publications