Zenth Health Sciences Division

Reprogramming the Immune System
For Precision Medicine

Aevum Zenth's immunotherapy platform leverages AI-driven target discovery, next-generation cellular engineering, and mRNA technologies to treat oncology, autoimmunity, and rare genetic disorders.

0 Clinical Programs
0 FDA Approved
0 Patients Enrolled
0 Global Trial Sites

Biology Meets Computation

A unified R&D ecosystem designed to accelerate discovery, reduce attrition, and deliver clinically transformative therapies.

🧬

AI-Driven Target Discovery

Proprietary machine learning models analyze multi-omic datasets to identify novel immune checkpoints, tumor antigens, and biomarker signatures with 94% predictive accuracy.

🔬

Cellular Engineering

Next-gen CAR-T, CAR-NK, and TCR-T platforms featuring optimized scFv binders, safety switches, and allogeneic off-the-shelf manufacturing capabilities.

💉

mRNA & Protein Therapeutics

LNP-delivered mRNA platforms enabling rapid antigen expression, neoantigen vaccines, and precise modulation of cytokine signaling pathways.

Clinical & Commercial Assets

From approved treatments to late-stage candidates across complex disease states.

Oncology

AZ-4091 (Carfilzellimab)

PD-1/LAG-3 bispecific antibody for advanced solid tumors and hematological malignancies.

Indication: NSCLC, Melanoma Commercial
Oncology

Zentecel-A (CAR-T)

Third-generation CD19/CD22 dual-targeting CAR-T for relapsed/refractory B-cell lymphomas.

Indication: DLBCL, CLL Phase III
Autoimmunity

AZ-2284 (CTLA-4 Idecabtagene)

IL-23 pathway inhibitor with enhanced tissue penetration for plaque psoriasis and Crohn's disease.

Indication: Psoriasis, IBD Phase III
Rare Disease

ZenthGene-RT (mRNA)

Personalized neoantigen vaccine platform for high-risk recurrence prevention in rare sarcomas.

Indication: Synovial Sarcoma Phase II
Oncology

AZ-1150 (Oncolytic Virotherapy)

Engineered HSV-1 expressing GM-CSF and IL-12 for intratumoral injection in pancreatic adenocarcinoma.

Indication: Pancreatic Cancer Phase II
Autoimmunity

AZ-3312 (Bispecific)

CD3/BCMA bispecific T-cell engager for multiple myeloma with reduced cytokine release syndrome risk.

Indication: Multiple Myeloma Phase III

Clinical Progression

Transparent tracking of our lead assets from discovery through regulatory submission.

Asset Code Modality Indication Phase Progress
AZ-4091 Bispecific Antibody Solid Tumors Commercial
Zentecel-A CAR-T Cell Non-Hodgkin Lymphoma Phase III
AZ-2284 Monoclonal Antibody Autoimmune Disorders Phase III
ZenthGene-RT mRNA Vaccine Rare Sarcomas Phase II
AZ-1150 Oncolytic Virus Pancreatic Cancer Phase II

CGMP-Compliant Infrastructure

Vertically integrated production ensuring scale, sterility, and rapid global deployment.

🏭

Biologics Campus (Neo Geneva)

120,000 ft² sterile fill-finish facility for monoclonal antibodies and bispecifics.

🧫

Cell Therapy Hub (Boston)

Automated CAR-T/NK processing with 48-hour turnaround and closed-system manufacturing.

🧪

mRNA & LNP Center (Singapore)

Rapid prototyping and scale-up for nucleic acid therapeutics and vaccines.

🌍

Global Distribution Network

Cold-chain logistics across 6 continents with real-time temperature monitoring.

Medical & Regulatory Disclaimer This page is for informational purposes only and does not constitute medical advice, treatment recommendations, or an offer to sell any investigational product. Aevum Zenth Health Sciences conducts clinical trials in strict compliance with FDA, EMA, and PMDA regulations. All pipeline data is preliminary and subject to change. Patients and physicians should consult official prescribing information for approved therapies.

Collaborate With Our Research Team

Whether you're a clinical investigator, biotech partner, or healthcare institution, explore how our immunotherapy platform can advance patient outcomes.

View Active Trials → Research Partnerships