Chen, W., Aevum Zenth Bioengineering, et al.
Nature Medicine | Vol 32, Issue 4 | March 2026 | DOI: 10.1038/s41591-026-03102-x
We report the first-in-human evaluation of ZENT-404, a lipid-nanoparticle encapsulated CRISPR-Cas12f system targeting PD-L1 and TIGIT co-expression pathways in advanced solid malignancies. Primary endpoints demonstrate sustained T-cell infiltration and acceptable safety profiles at escalating doses up to 5×10^13 vg/kg...
Rossi, M., Aevum Zenth Neural Therapeutics, et al.
The Lancet Oncology | Vol 27, Issue 2 | Feb 2026 | DOI: 10.1016/S1470-2045(26)00041-9
Intraventricular delivery of IL-12 engineered CAR-T cells demonstrates prolonged central nervous system persistence and reduced neuroinflammatory cytokine release compared to first-generation constructs. Median progression-free survival reached 14.2 months in refractory GBM cohorts...
Patel, N., Aevum Zenth AI Diagnostics, et al.
Science Translational Medicine | Vol 17, Issue 8 | Nov 2025 | DOI: 10.1126/scitranslmed.adk1029
Integration of multi-omic plasma profiles with transformer-based architectures achieves 94.7% sensitivity for stage I/II PDAC detection in asymptomatic populations. The Zenth OncoScan panel identifies circulating exosomal miRNA signatures correlated with KRAS mutation burden...
Kumar, S., Aevum Zenth Regenerative Bio, et al.
Cell Stem Cell | Vol 30, Issue 5 | Oct 2025 | DOI: 10.1016/j.stem.2025.08.003
Microfluidic patterning of iPSC-derived endocrine progenitors yields immunoevasive, glucose-responsive islet-like clusters. Xenograft transplantation in NOD-SCID mice demonstrates sustained C-peptide secretion and insulin independence for 18 months without systemic immunosuppression...
Larsen, J., Aevum Zenth Vaccinology, et al.
JAMA Oncology | Vol 11, Issue 8 | Sept 2025 | DOI: 10.1001/jamaoncol.2025.1892
Administration of lipid-encapsulated HPV16/18 E6/E7 mRNA constructs significantly reduced recurrence rates in post-surgical oropharyngeal carcinoma patients. Immune memory formation persisted at 24 months with robust CD8+ T-cell clonal expansion and neutralizing antibody titers...