142
Active Trials
38
Recruiting Now
24
Countries
94%
On-Time Completion

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Showing 5 of 142 trials
Recruiting
ZHS-ONC-2024-042

Efficacy and Safety of Zenth-Alpha in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)

A randomized, double-blind, placebo-controlled Phase 3 study evaluating Zenth-Alpha monotherapy versus standard of care in treatment-naïve patients with EGFR-mutated NSCLC. Primary endpoint: Progression-Free Survival (PFS).

Phase 3
1,200 Participants
USA, UK, Japan, Germany
Oncology Lung Cancer EGFR Small Molecule
Zenth AI High Match
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Recruiting
ZHS-NEU-2024-018

Zenth-NeuroX for the Treatment of Early-Onset Alzheimer's Disease

An open-label, Phase 2 study assessing the safety and cognitive efficacy of Zenth-NeuroX, a monoclonal antibody targeting amyloid-beta plaques, in patients with mild cognitive impairment due to early-onset Alzheimer's.

Phase 2
450 Participants
USA, Canada, Australia
Neurology Alzheimer's Monoclonal Antibody
Active
ZHS-RARE-2023-009

Gene Therapy ZHS-GT12 for Spinal Muscular Atrophy Type 1 (SMA1)

A Phase 3, single-arm study evaluating the intravenous administration of ZHS-GT12, an AAV9-based gene therapy, in infants with SMA1. Primary outcome: Achievement of motor milestones at 18 months.

Phase 3
80 Participants
Global Multi-Center
Rare Disease Gene Therapy Pediatrics
Completed
ZHS-ONC-2022-114

Zenth-CytoK as Maintenance Therapy in Metastatic Melanoma

Completed Phase 3 study demonstrating significant improvement in Overall Survival with Zenth-CytoK maintenance compared to placebo in patients with resected Stage III melanoma. Data led to accelerated regulatory approval.

Phase 3
900 Participants
12 Countries
Oncology Melanoma Immunotherapy Approved
Pending Review
ZHS-CVR-2025-001

Cardio-StemX for Heart Failure with Reduced Ejection Fraction (HFrEF)

Upcoming Phase 2 study evaluating autologous cardiac stem cell therapy in patients with HFrEF. Protocol currently under IRB review. Anticipated start date: Q2 2025.

Phase 2 (Planned)
300 Participants
USA, Europe
Cardiology Stem Cell Regenerative Medicine
View All 142 Trials

Targeting High-Unmet Needs

Zenth Health Sciences prioritizes research areas with significant unmet medical needs, leveraging our conglomerate's AI and advanced manufacturing capabilities.

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Oncology

Novel targeted therapies, immunotherapies, and combination approaches for solid and hematologic malignancies.

68 Active Trials
🧠

Neurology

Breakthroughs in neurodegenerative diseases, neuromuscular disorders, and CNS therapeutics using Zenth-AI drug discovery.

34 Active Trials

Rare Diseases

Gene therapies and orphan drugs for ultra-rare conditions, powered by our specialized Aevum Rare Disease Unit.

21 Active Trials
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Infectious Diseases

Rapid-response vaccine platforms and next-generation antimicrobials, integrated with Zenth Biosafety facilities.

12 Active Trials
❤️

Cardiology

Regenerative cardiology, metabolic interventions, and novel anticoagulants for cardiovascular health.

7 Active Trials
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Rheumatology & Autoimmune

Biologic and small molecule therapies for autoimmune disorders, focusing on remission and safety.

19 Active Trials

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